The average cooking temperature of a Crock-Pot on the low setting is around 170°F to 200°F (approximately 77°C to 93°C). This low and slow cooking temperature allows for tenderizing and slow cooking of ingredients, making it ideal for stews, soups, and other slow-cooked dishes. However, it's essential to note that the actual temperature can vary slightly depending on the specific model and brand of the Crock-Pot.