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Cooking a 5-pound pork tenderloin in a slow cooker will take a considerable amount of time to ensure it becomes tender and fully cooked. However, it's essential to note that pork tenderloin is a lean cut of meat, and it's not typically the best choice for slow cooking as it can easily become overcooked and dry. For slow cooking, cuts like pork shoulder or pork butt are better options due to their higher fat content, which keeps them moist and flavorful during the long cooking process.

If you still want to proceed with the 5-pound pork tenderloin in the slow cooker, here are some general guidelines:

Cooking Time: On low heat, a 5-pound pork tenderloin may take around 4 to 6 hours to cook. On high heat, it could take around 2 to 3 hours. However, cooking times can vary depending on your slow cooker's specific settings and the thickness of the tenderloin.

Recommendation: To avoid the risk of overcooking and drying out the tenderloin, it's better to cook it on the low setting. Cooking on low allows the meat to cook slowly and stay tender, whereas cooking on high may make it more susceptible to becoming tough and dry.

Internal Temperature: Regardless of the cooking time, it's crucial to use a meat thermometer to check the internal temperature of the pork tenderloin. Pork should reach a minimum internal temperature of 145°F (63°C) for safe consumption. However, if you prefer your pork slightly pink, it's safe to cook it to 140°F (60°C) and allow it to rest for a few minutes before serving.

Liquid: Since pork tenderloin is lean and can dry out easily, you may want to add some liquid to the slow cooker to help keep it moist. You can use chicken or vegetable broth, apple juice, or even a mixture of BBQ sauce and water to add flavor.

Searing: To enhance the flavor and appearance of the pork, consider searing it in a hot skillet before placing it in the slow cooker. Searing creates a crust on the surface of the meat, sealing in the juices and adding delicious caramelized flavors.

If possible, consider using a different cut of pork like pork shoulder or pork butt for slow cooking. These cuts are more forgiving and are better suited for long, slow cooking methods like braising or roasting. Pork tenderloin is best suited for quicker cooking methods like roasting, grilling, or pan-searing to retain its tenderness and juiciness.

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