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Consuming open Betty Crocker frosting that has been left at room temperature for two weeks is not recommended. Leaving perishable food items, like frosting, at room temperature for an extended period can lead to the growth of harmful bacteria and may cause foodborne illnesses.

Frostings, especially those containing dairy or other perishable ingredients, are susceptible to spoilage and can become a breeding ground for bacteria when stored improperly. The label on the frosting container likely advises refrigeration to maintain its freshness and safety.

If the frosting looks or smells unusual, or if you notice any signs of mold, discoloration, or separation, it is best to discard it to avoid the risk of food poisoning. Consuming spoiled food can lead to various health issues and is not worth the potential risks.

In the future, always follow the storage instructions on food labels and be sure to refrigerate perishable items promptly to maintain their quality and safety. When in doubt, it's better to err on the side of caution and discard any food that you suspect might not be safe to eat.

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