Cooking times for turkeys can vary depending on various factors, including whether the turkey is stuffed or unstuffed, the specific oven used, and the desired level of doneness. As a general guideline, it's recommended to cook a 22 lb turkey at 350 degrees Fahrenheit (175 degrees Celsius) for approximately 4.5 to 5 hours if it is unstuffed.
However, to ensure that the turkey is cooked safely and thoroughly, it's essential to use a meat thermometer. The internal temperature of the thickest part of the turkey (typically the thigh) should reach a minimum of 165 degrees Fahrenheit (74 degrees Celsius) to be safe to eat.
Keep in mind that these are general guidelines, and it's always best to refer to the cooking instructions provided with the turkey or consult with a reliable recipe source for more precise cooking times and techniques. Additionally, allow some extra time for preparation, resting, and carving the turkey before serving.